Natural infection of swiss mice with Mouse Mammary Tumor Virus (MMTV): Viral expression in milk and transmission of infection

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Abstract
Quantitative determinations of gp52, the main envelope glycoprotein, and p28, the main core protein, of MMTV, have been performed in about 1000 individual samples of milk of breeding females from our colony of MMTV-infected Swiss mice, a line characterized by a moderate incidence of mammary tumors. A computer analysis of the results showed: 1— an important individual variation, ranging from 0 to 120µg per ml of milk for p28, and from 0 to 320 µg per ml of milk for gp52; 2— a variation of the release of both antigens during a single lactation, with a maximum on the 7–8th day of nursing; 3— an increase of the release of both antigens with parity up to the 6th lactation, followed by a marked decrease during later lactations; 4— a higher degree of infection in the offspring of 2nd and 3rd litters. The possible dependence of viral expression and transmission of infection upon factors such as cyclic activity of the mammary gland and progressive immunization of mice against MMTV is analyzed. The status of our laboratory line of MMTV infected Swiss mice is discussed in comparison with high and low tumor incidence strains.

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