The MutS C Terminus Is Essential for Mismatch Repair Activity In Vivo
- 15 September 2005
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 187 (18) , 6577-6579
- https://doi.org/10.1128/jb.187.18.6577-6579.2005
Abstract
An Escherichia coli K-12 strain was constructed with a chromosomal deletion (mutSΔ800) in the mutS gene that produced the removal of the C-terminal 53 amino acids which are not present in the MutS crystal structure. This strain has a MutS null phenotype for mutation avoidance, antirecombination, and sensitivity to cytotoxic agents in a dam mutant background.Keywords
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