Potentiometric and spectroscopic study of the equilibria in the aqueous copper(II)–3,6-diazaoctane-1,8-diamine system and an equilibrium-di-alysis examination of the ternary system of human serum albumin–copper(II)–3,6-diazaoctane-1,8-diamine

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Abstract
3,6-Diazaoctane-1,8-diamine (L, trien) has been obtained by a new purification method, and used in a combined potentiometric and spectroscopic study of the total species formed with CuII(M) in 0.15 mol dm–3 NaCl solution at 25 °C over the range pH 3.0–10.0. The species found are MHL, MH–1L, ML, MH4L2, MH3L2, and ML2, with log stability constants 23.76, 9.39, 20.01, 52.78, 48.52, and 22.87 respectively. The concentrations of the species, over the range pH 3.0–10.0, and their spectroscopic characteristics have been determined. Equilibrium-dialysis studies of the ternary systems: albumin–copper(II)–ligand (ligand = 3,6-diazaoctane-1,8-diamine or D-penicillamine) have been carried out in 0.15 mol dm–3 NaCl solution, pH 7.47, at 6 °C, to measure the amounts of low-molecular-weight membrane-diffusable copper(II) species formed. There is a substantial difference between the two ligands in this respect which correlates with their different clinical behaviour when used in the treatment of patients having Wilson's disease.

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