Suppression of experimental crescentic glomerulonephritis by peroxisome proliferator-activated receptor (PPAR)? activators
- 1 March 2003
- journal article
- research article
- Published by Springer Nature in Clinical and Experimental Nephrology
- Vol. 7 (1) , 27-32
- https://doi.org/10.1007/s101570300003
Abstract
Background. It has been recently reported that peroxisome proliferator-activated receptors (PPARs)γ exist in various tissues and that they exibit anti-inflammatory effects. Methods. We investigated the effects of PPARγ activators on the development of crescentic glomerulonephritis. Crescentic glomerulonephritis was induced by the injection of rabbit anti-rat glomerular basement membrane antibody in WKY rats. Results. Administration of troglitazone suppressed urinary protein excretion and crescent formation as indicated by crescent scores. Pioglitazone, a PPARγ activator, mimicked the effect of troglitazone, but bezafibrate, a PPARα-activator, did not. Immunohistology revealed that troglitazone and pioglitazone inhibited the infiltration of ED-1-positive monocyte/macrophages and CD8-positive cells into glomeruli. Conclusions. In the present study, we demonstrated that PPARγ activators exert antinephritic effects by suppressing the recruitment of inflammatory cells via a PPARγ-dependent mechanism.Keywords
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