A Novel Inhibitor of Gamma‐Aminobutyrate Aminotransferase with Anorectic Activity
- 1 July 1982
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 39 (1) , 271-273
- https://doi.org/10.1111/j.1471-4159.1982.tb04733.x
Abstract
1-(n-decyl)-3-Pyrazolidinone (BW357U) is a potent, selective inhibitor of gamma-aminobutyrate aminotransferase (GABA-T) in vitro and in vivo. After acute or chronic, oral or intraperitoneal administration of BW357U to rats, brain GABA levels were elevated in a dose-dependent manner. When inhibition of brain GABA-T exceeded 50%, whole brain GABA levels were elevated approximately threefold, and an anorectic effect was observed in the absence of other symptoms. This compound, because of its potency and selectivity, may be useful in studies relating to the function of GABA-containing neurons in appetite regulation.Keywords
This publication has 9 references indexed in Scilit:
- The pharmacology of GABA-transaminase inhibitorsBiochemical Pharmacology, 1981
- Anorexic effects of ethanolamine-O-sulfate and muscimol in the rat: Evidence that GABA inhibits ingestive behaviorLife Sciences, 1980
- Inhibitors of GABA metabolismBiochemical Pharmacology, 1979
- GABA: Circadian fluctuations in rat hypothalamusJournal of Neurochemistry, 1978
- GABA‐TRANSAMINASES OF HUMAN BRAIN AND PERIPHERAL TISSUES—KINETIC AND MOLECULAR PROPERTIESJournal of Neurochemistry, 1978
- Effects of gabaculine, a new potent inhibitor of gamma-aminobutyrate transaminase, on the brain gamma-aminobutyrate content and convulsions in miceLife Sciences, 1977
- THE EFFECT OF 4‐AMINO HEX‐5‐YNOIC ACID (γ‐ACETYLENIC GABA, γ‐ETHYNYL GABA) A CATALYTIC INHIBITOR OF GABA TRANSAMINASE, ON BRAIN GABA METABOLISM IN VIVOJournal of Neurochemistry, 1977
- SUSTAINED DRUG‐INDUCED ELEVATION OF BRAIN GABA IN THE RAT1Journal of Neurochemistry, 1973
- Fluorometric determination of aspartate, glutamate, and γ-aminobutyrate in nerve tissue using enzymic methodAnalytical Biochemistry, 1966