Reduction of lnterleukin‐2‐Receptor Expression on Retroplacental Blood Lymphocytes in Human Pregnancy

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Abstract
Retroplacental blood lymphocytes (RPL) in human pregnancy were studied for proliferative response induced by recombinant interleukin‐2 (rIL‐2) and anti‐Tac positive cells before and after PHA stimulation for 24 hr and compared with peripheral blood lymphocytes (PBL) of the same donor. Proliferation of RPL induced by IL‐2 was significantly lower than that of PBL in all of six cases. In addition, flow cytometry analysis of IL‐2 receptors (IL‐2R) revealed that IL‐2R expression of RPL after stimulation with PHA for 24 hr was significantly less than that of PBL in three of four cases and that RPL showed significantly fewer IL‐2R than PBL even at resting state in one case. These results suggest that RPL seem likely to be composed of reduced numbers of lymphocytes bearing IL‐2R of non‐Tac protein and to have impaired capacity for the acquisition of high‐affinity receptors for IL‐2.