INCREASE IN THE FORMATION AND SECRETION OF ACTH FOLLOWING ADRENALECTOMY1
- 1 September 1951
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 49 (3) , 325-336
- https://doi.org/10.1210/endo-49-3-325
Abstract
The adrenal gland through its formation of cortical steroids controls formation and secretion of ACTH by the pituitary. Removal of the adrenals is reflected in an immediate and progressive increase in ACTH secretion. This causes pituitary ACTH content to drop until progressively increasing ACTH formation in the gland causes it to rise again. Adrenalectomy does not appreciably affect the ACTH space or the disappearance rate of ACTH. Three weeks after adrenalectomy, a new approx. steady state is reached, characterized by a content of ACTH in the pituitary 1 and 1.5 times normal, an increased ACTH content in the body fluids at least 30 times that found normally, and an increased ACTH formation and secretion rate at least 30 times normal.Keywords
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