The Synthesis of 3-Substituted Pyrrole-2,4-dicarboxylic Acid Esters: Reaction of Methyl Isocyanoacetate with Aldehydes
- 1 November 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in Agricultural and Biological Chemistry
- Vol. 40 (11) , 2271-2274
- https://doi.org/10.1080/00021369.1976.10862374
Abstract
A one-step synthesis of dimethyl 3-substituted pyrrole-2, 4-dicarboxylates by the reaction of methyl isocyanoacetate with various aldehydes in the presence of DBU was carried out. Furthermore, the reaction mechanism was investigated; it was found that the methyl α-isocyanoacrylate compound is a key intermediate of the pyrrole compound.This publication has 1 reference indexed in Scilit:
- A Stereoselective Synthesis ofthreo-Threonine Reaction of Isocyanoacetate with AcetaldehydeAgricultural and Biological Chemistry, 1976