Evaluation of Indirect Hemagglutination and Its Inhibition in the Differentiation between Antibodies to Herpes Simplex Virus Types 1 and 2 for Seroepidemiologic Studies: Use of a II/I Index Threshold of 85 and an Assay of Type-Specific Antibodies

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Abstract
Two parameters, a II/I index threshold value of 85 and an assay of type-specific antibodies to herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), were assessed, for seroepidemiologic purposes, for their efficacy in the establishment of past infections with HSV-1 and HSV-2 as indicated by the results of tests for indirect hemagglutination and its inhibition. Neither criterion alone established past infection with either HSV-1 or HSV-2. However, by combination of the two parameters, antibodies to HSV-1 and HSV-2 could be differentiated for seroepidemiologic studies.