Can hepatic coma be caused by a reduction of brain noradrenaline or dopamine?
Open Access
- 1 September 1977
- Vol. 18 (9) , 688-691
- https://doi.org/10.1136/gut.18.9.688
Abstract
Intraventricular infusions of octopamine which raised brain octopamine concentrations more than 20 000-fold resulted in reductions in brain noradrenaline and dopamine by as much as 90% without affecting the alertness or activity of normal rats. As this reduction of brain catecholamines is much greater than any reported in hepatic coma, we do not believe that values observed in experimental hepatic failure have aetiological significance for the encephalopathy that ensues.This publication has 14 references indexed in Scilit:
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