THE MECHANISMS OF RAYNAUD'S PHENOMENON: PART 1

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Abstract
Raynaud's phenomenon Is the direct result of altered hæmodynamics In the vessels of the hand and is a well‐recognized complication of many diseases. This review summarizes current concepts of the various hæmodynamic factors Involved in the normal control of the circulation through the hand and digits, and applies these concepts to a consideration of the mechanisms responsible for Raynaud's phenomenon and digital ischæmia. The physiology of the peripheral circulation Is discussed In detail and the flow characteristics of blood (I.e., blood rheology) are also considered. Because of the accessibility of the peripheral circulation, clinical observations can be readily correlated with measurements from studies of vascular physiology and rheology. This interdisciplinary approach is essential to the understanding of circulatory dynamics and their disturbances In Raynaud's phenomenon, and may also be relevant to the Interpretation of concurrent disease occurring in other vascular beds. The immediate gains from this approach will also include the more effective management of Raynaud's phenomenon in particular, and peripheral vascular disease in general.

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