Activation of the human diaphragm from the motor cortex.
Open Access
- 1 March 1987
- journal article
- research article
- Published by Wiley in The Journal of Physiology
- Vol. 384 (1) , 109-118
- https://doi.org/10.1113/jphysiol.1987.sp016445
Abstract
1. Rapidly conducting corticofugal pathways were activated by percutaneous electrical stimulation of the motor cortex in normal subjects. The electromyographic response produced in the diaphragm was assessed with recordings via a gastro‐oesophageal catheter and the mechanical response was measured as a change in transdiaphragmatic pressure. 2. The mean latency from the cortical stimulus to the muscle action potential in the diaphragm was 12.3 ms. The latency to the diaphragm from stimulation of the cervical spinal cord at the C4 level was 8.0 ms. The mean 'central conduction time' to the phrenic motor nucleus of 4.3 ms (range 4.0‐4.6 ms) was similar to that for the deltoid (mean 4.4 ms; range 4.0‐4.8 ms) recorded in the same subjects. 3. The largest twitch contractions of the diaphragm were evoked by cortical stimuli near the vertex during inspiration. The amplitude and duration of the electromyographic and mechanical responses often exceeded those produced by a supramaximal stimulus to both phrenic nerves simultaneously. 4. These results provide the first direct evidence that there is a rapidly conducting oligosynaptic pathway from the motor cortex to the human diaphragm.This publication has 25 references indexed in Scilit:
- Motor conduction velocity in the human spinal cord: slowed conduction in multiple sclerosis and radiation myelopathy.Journal of Neurology, Neurosurgery & Psychiatry, 1985
- Nervous propagation along ‘central’ motor pathways in intact man: Characteristics of motor responses to ‘bifocal’ and ‘unifocal’ spine and scalp non-invasive stimulationElectroencephalography and Clinical Neurophysiology, 1985
- Nerve impulse propagation along central and peripheral fast conducting motor and sensory pathways in manElectroencephalography and Clinical Neurophysiology, 1985
- The identification of brainstem neurones projecting to thoracic respiratory motoneurones in the cat as demonstrated by retrograde transport of HRPBrain Research Bulletin, 1985
- Assessment of human diaphragm strength and activation using phrenic nerve stimulationRespiration Physiology, 1984
- ABNORMALITIES IN CENTRAL MOTOR PATHWAY CONDUCTION IN MULTIPLE SCLEROSISThe Lancet, 1984
- Stimulation of the cerebral cortex in the intact human subjectNature, 1980
- Localization in somatic sensory and motor areas of human cerebral cortex as determined by direct recording of evoked potentials and electrical stimulationJournal of Neurosurgery, 1979
- The descending respiratory pathway in manJournal of Neurology, Neurosurgery & Psychiatry, 1963
- Effet de la Stimulation du Cortex Moteur sur l'ActiviteA EAlectrique des Nerfs PhreAniques et MeAdiansArchives Internationales de Physiologie et de Biochimie, 1958