The synthesis of some 32-functionalised lanostane derivatives
- 1 January 1972
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- Vol. 5, 739-748
- https://doi.org/10.1039/p19720000739
Abstract
Lanosterol has been converted into 3β-acetoxylanost-7-en-32-onitrile and thence into 3β-acetoxylanost-7-en-32-al and 3β,32-diacetoxylanost-7-ene. 3β-Acetoxy-11-oxolanost-8-en-32-onitrile and methyl 3β-acetoxy-32-nitrilo-11-oxo-25,26,27-trinorlanost-8-en-24-oate have been synthesised by an analogous route. Unsuccessful attempts to prepare 3β-acetoxylanost-7-en-32-oic acid are reported, together with some novel methods for the oxidation of sterically hindered aldehydes as exemplified by using pivalaldehyde as a model compound.Keywords
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