Negative selection — clearing out the bad apples from the T-cell repertoire
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- 1 May 2003
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 3 (5) , 383-391
- https://doi.org/10.1038/nri1085
Abstract
Dead cells are a prominent feature of the thymic landscape as only 5% of developing thymocytes are exported as mature T cells. The remaining thymocytes die by one of two mechanisms; most thymocytes die because they are not positively selected and do not receive a survival signal, whereas a minority of thymocytes undergo T-cell receptor (TCR)-mediated apoptosis, a process known as negative selection. Negative selection is extremely important for establishing a functional immune system, as it provides an efficient mechanism for ridding the T-cell repertoire of self-reactive and potentially autoimmune lymphocytes. This review discusses several cellular and molecular aspects of negative selection.Keywords
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