Selective Formation of 2-Hydroxy-3,3-bis(hydroxymethyl)-γ-butyrolactone from Formaldehyde on Hydrotalcite-Type Catalysts
- 1 February 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 69 (2) , 425-429
- https://doi.org/10.1246/bcsj.69.425
Abstract
As a model for prebiotic sugar formation under neutral to acidic conditions, reactions of formaldehyde over hydrotalcite-type catalysts were investigated. Heating an aqueous solution of formaldehyde at 140—200 °C for 12 h over Ni–Fe hydrotalcite-type catalyst afforded 2-hydroxy-3,3-bis(hydroxymethyl)-γ-butyrolactone selectively, a 5.8% yield based on gas–liquid chromatographic analysis. The structure was identified by 1H and 13C NMR and 1H–13C HSQC, HMBC and 13C–13C 2D INADEQUATE NMR experiments.Keywords
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