Spontaneous Leukemia at High Altitude in C58 Mice2

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Abstract
A lower incidence of spontaneous leukemia was found in 329 C58 mice kept at high altitude than in 448 mice of the same strain kept at sea level. The difference was statistically significant. The amount of infiltration by leukemic cells and the weights of the localized tumors were greater in mice kept at sea level than in mice kept at high altitude. No difference in histology or cytology of the neoplasms could be detected. Leukemia occurred more often in female than in male mice, irrespective of altitude. A lower incidence was found in males kept at high altitude than in males kept at sea level, and the difference was statistically significant. The difference in the females was not so great but also was higher at sea level.

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