Nitric oxide synthase expression and function in embryonic and adult cardiomyocytes
- 15 November 2001
- journal article
- research article
- Published by Wiley in Microscopy Research and Technique
- Vol. 55 (4) , 259-269
- https://doi.org/10.1002/jemt.1175
Abstract
Nitric oxide (NO) is an important signalling molecule that plays a relevant role in different cell systems, among them the adult heart. The effects of NO are primarily mediated through modulation of Ca2+ homeostasis, myofibrillar contractility, and metabolic regulation in cardiomyocytes. Recent evidence also suggests an important role of NO for cardiomyogenesis by modulating proliferation and differentiation and regulating cardiac function. In the embryonic, but also the healthy and diseased, adult mammalian heart, the inducible (iNOS) and the endothelial (eNOS) nitric oxide synthases (NOS) are detected. However, the expression pattern of NO and its function differ during development. Furthermore, under pathophysiological conditions NOS expression can also change and cause impairment of cardiac performance and cytotoxic effects. The present review focuses on the role and function of NO during cardiomyogenesis, the mechanisms responsible for eNOS availability, and the paracrine effects of NO generated by cardiomyocytes. Microsc. Res. Tech. 55:259–269, 2001.Keywords
This publication has 116 references indexed in Scilit:
- Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxidePublished by Wiley ,2001
- Activation of Nitric Oxide Synthase (NOS3) by Mechanical Activity Alters Contractile Activity in a Ca2+-Independent Manner in Cardiac Myocytes: Role of Troponin I PhosphorylationBiochemical and Biophysical Research Communications, 1999
- AMP‐activated protein kinase phosphorylation of endothelial NO synthaseFEBS Letters, 1999
- Caveolin-1 Detergent Solubility and Association with Endothelial Nitric Oxide Synthase Is Modulated by Tyrosine PhosphorylationBiochemical and Biophysical Research Communications, 1997
- Muscarinic regulation of the L-type calcium current in isolated cardiac myocytesLife Sciences, 1997
- Bradykinin-Stimulated Protein Tyrosine Phosphorylation Promotes Endothelial Nitric Oxide Synthase Translocation to the CytoskeletonBiochemical and Biophysical Research Communications, 1996
- Cyclic AMP Augments Cytokine-stimulated Nitric Oxide Synthesis in Rat Cardiac MyocytesJournal of Molecular and Cellular Cardiology, 1996
- Molecular Cloning of Caveolin-3, a Novel Member of the Caveolin Gene Family Expressed Predominantly in MuscleJournal of Biological Chemistry, 1996
- Nitric Oxide Potently and Reversibly Deenergizes Mitochondria at Low Oxygen TensionBiochemical and Biophysical Research Communications, 1994
- Cloned human brain nitric oxide synthase is highly expressed in skeletal muscleFEBS Letters, 1993