Effect of Niosome Encapsulation of Methotrexate, Macrophage Activation on Tissue Distribution of Methotrexate and Tumor Size
- 1 January 1993
- journal article
- research article
- Published by Taylor & Francis in Drug Delivery
- Vol. 1 (2) , 133-137
- https://doi.org/10.3109/10717549309022767
Abstract
Methotrexate was encapsulated in “niosomes” of sorbitan monostearate (Span 60) by the reverse phase evaporation technique. After i.v. infusion into mice methotrexate concentration was higher in all tissues except kidney with niosomal methotrexate than with methotrexate solution. Niosome encapsulation and macrophage activation enhanced the delivery of methotrexate to the tumor and increased its antitumor activity.Keywords
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