Cardiovascular and pancreatic endocrine responses to glucagon‐like peptide‐1(7–36) amide in the conscious calf

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Abstract
Intravenous infusions of glucagon‐like peptide‐1(7‐36) amide (GLP‐1; 35 pmol min‐1 kg‐1 for 10 min) produced a significant rise in mean heart rate, without significant change in mean aortic blood pressure, together with a significant rise in mean arterial plasma insulin, but not in plasma pancreatic glucagon or pancreatic polypeptide concentration, in conscious calves given exogenous glucose (30‐60 micromol min‐1 kg‐1 i.v.). The insulinotropic effect was eliminated in the presence of exogenous amino acids (0.03 mmol min‐1 kg‐1 i.v.). It was not affected predictably by blocking the synthesis of nitric oxide or by the simultaneous administration of the established incretin factor gastrin‐releasing peptide (GRP). Whereas GLP‐1 produced a statistically significant rise in plasma insulin concentration in these animals, it was much less effective than GRP in this respect, when given by continuous i.v. infusion.

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