Fabrication of Plastic Microfluid Channels by Imprinting Methods
- 1 December 1997
- journal article
- research article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 69 (23) , 4783-4789
- https://doi.org/10.1021/ac970558y
Abstract
Microfluidic devices have been fabricated on poly(methyl methacrylate) substrates by two independent imprinting techniques. First-generation devices were fabricated using a small-diameter wire to create an impression in plastics softened by low-temperature heating. The resulting devices are limited to only simple linear channel designs but are readily produced at low cost. Second-generation devices with more complex microchannel arrangements were fabricated by imprinting the plastic substrates using an inverse three-dimensional image of the device micromachined on a silicon wafer. This micromachined template may be used repeatedly to generate devices reproducibly. Fluorescent analtyes were used to demonstrate reproducible electrophoretic injections. An immunoassay was also performed in an imprinted device as a demonstration of future applications.Keywords
This publication has 17 references indexed in Scilit:
- UV Laser Machined Polymer Substrates for the Development of Microdiagnostic SystemsAnalytical Chemistry, 1997
- Integrated Capillary Electrophoresis Devices with an Efficient Postcolumn Reactor in Planar Quartz and Glass ChipsAnalytical Chemistry, 1996
- Microchip Electrophoretic Immunoassay for Serum CortisolAnalytical Chemistry, 1996
- Ultra-High-Speed DNA Sequencing Using Capillary Electrophoresis ChipsAnalytical Chemistry, 1995
- Silicon wafer integrated enzyme reactorsBiosensors and Bioelectronics, 1995
- A novel approach to ion separations in solution: synchronized cyclic capillary electrophoresis (SCCE)Sensors and Actuators B: Chemical, 1994
- Glass chips for high-speed capillary electrophoresis separations with submicrometer plate heightsAnalytical Chemistry, 1993
- Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a ChipScience, 1993
- Planar glass chips for capillary electrophoresis: repetitive sample injection, quantitation, and separation efficiencyAnalytical Chemistry, 1993
- Capillary electrophoresis and sample injection systems integrated on a planar glass chipAnalytical Chemistry, 1992