Primary nodal marginal zone B‐cell lymphoma: clinical features and prognostic assessment of a rare disease

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Abstract
Summary: This study defined the clinical features and assessed the prognosis of 47 patients (17 males, 30 females, median age 63 years) with primary nodal marginal zone B‐cell lymphoma. Forty‐five per cent had stage IV disease. Hepatitis C virus serology was positive in 24%. According to the Follicular Lymphoma International Prognostic Index (FLIPI), 33% were classified as low‐risk, 34% as intermediate‐risk, and 33% as high‐risk. The 5‐year overall survival (OS) was 69%. In univariate analysis worse OS was associated with: FLIPI (P = 0·02), age > 60 years (P = 0·05) and raised lactate dehydrogenase (P = 0·05). In multivariate analysis, only FLIPI predicted a worse OS (P = 0·02).