A Physiological Basis for Autonomous Growth of the Crown-Gall Tumor Cell

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Abstract
Experimental evidence which demonstrates that as the crown-gall tumor cell becomes more autonomous, its requirements in terms of externally supplied growth factors become less exacting. During the transition from the normal cell to the fully altered tumor cell, a series of well-defined growth substance synthesizing systems become gradually activated, apparently determined by the rate of growth of the tumor cell. The continued production in greater than regulatory amounts of these substances by the tumor cell probably accounts for the continued unregulated proliferation of such a cell. According to the author, results of these studies suggest that it is possible for a cell to acquire the capacity for autonomous growth as a result of a permanent activation of a series of growth substance synthesizing systems, the products of which are concerned specifically with growth accompanied by cell division.