Differential expression of CD45RO (UCHL1) and its functional relevance in two subpopulations of circulating TCR-gamma/delta+ lymphocytes.

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Abstract
We examined the developmental profile of TCR-.gamma./.delta.+ cells with respect to CD45RO expression. Although total TCR-.gamma./.delta.+ cells were negligible in the neonatal blood and increased with advancing age, most blood TCR-.gamma./.delta.+ cells markedly expressed CD45RO without a distinction of age, probably reflecting a different CD45RO expression of two subsets defined by BB3 and .delta.TCS1 mAbs. The vast majority of BB3+ cells expressed CD45RO, whereas expression of CD45RO was virtually absent in the .delta.TCS1+ population. Functional studies revealed that, while both TCR-.gamma./.delta.+ cell subsets showed CD3-mediated activation, only BB3+ (or Ti.gamma.A+) cells, but not .delta.TCS1+ cells, appeared to proliferate in response to PPD in PPD-reactive individuals. The results suggested that the CD45RO+ (BB3+ or Ti.gamma.A+) subset among blood TCR-.gamma./.delta.+ cells may be mainly involved in the memory or primed component of the immune system responding to some foreign antigens.

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