Junctional CD8+ Cutaneous Lymphomas With Nonaggressive Clinical Behavior
Open Access
- 1 February 2002
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 138 (2) , 199-203
- https://doi.org/10.1001/archderm.138.2.199
Abstract
MOST CUTANEOUS T-cell lymphomas (CTCLs) have the phenotype of T-helper memory lymphocytes (CD3+, CD4+, and CD45R0+).1,2 Only a minority of cases present with other phenotypes, such as CD3+, CD4−, CD8−, or CD3+CD8+,3,4 or with the spectrum of CD56+ lymphomas.5-7 The primary cutaneous lymphomas with the phenotype of cytotoxic/suppressor (CD8+) T cells have been of significant interest in the recent literature.8-12 The detailed analysis of histological and clinical features in several cases has led to the conclusion that CD8+ T-cell lymphomas represent a distinct type of CTCL with an aggressive clinical behavior.4,12Keywords
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