Regulation of cell proliferation and cell death by peroxisome proliferators
- 5 May 2003
- journal article
- review article
- Published by Wiley in Microscopy Research and Technique
- Vol. 61 (2) , 179-184
- https://doi.org/10.1002/jemt.10327
Abstract
Peroxisome proliferators cause increases in liver mass in rodents, linked to changes in cell proliferation and cell death of hepatocytes. These effects are reversible upon cessation of treatment. The underlying mechanism of the response in rodent liver is complex, but clearly dependent on activation of the nuclear receptor PPARα. Other signaling pathways have been implicated in this response, but evidence is mixed. Differing sensitivity among various species to effects of peroxisome proliferators has been associated with differences in PPARα expression and function. Changes in cell proliferation and cell death in neoplastic hepatocytes also have been found in liver tumors caused by long‐term treatment with peroxisome proliferators. Microsc. Res. Tech. 61:179–184, 2003.Keywords
This publication has 41 references indexed in Scilit:
- Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: role of PPARα and TNFαMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2000
- Species differences in hepatic peroxisome proliferation, cell replication and transforming growth factor-β1 gene expression in the rat, Syrian hamster and guinea pigMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2000
- Liver regenerationJournal of Hepatology, 2000
- Transcriptional Regulatory Signals Define Cytokine-Dependent and -Independent Pathways in Liver RegenerationSeminars in Liver Disease, 1999
- Liver Cell Proliferation Induced by Nafenopin and Cyproterone Acetate Is Not Associated With Increases in Activation of Transcription Factors Nf–κB and Ap–1 or With Expression of Tumor Necrosis Factor αHepatology, 1997
- Effect on the expression of c-met, c-myc and PPAR-α in liver and liver tumors from rats chronically exposed to the hepatocarcinogenic peroxisome proliferator WY-14, 643Carcinogenesis: Integrative Cancer Research, 1996
- Comparison of the acute and chronic mitogenic effects of the peroxisome proliferators methylclofenapate and clofibric acid in rat liverCarcinogenesis: Integrative Cancer Research, 1993
- Differences in the steady-state levels of c- fos , c- jun and c- myc messenger RNA during mitogen-induced liver growth and compensatory regenerationHepatology, 1993
- Contrasting hepatocytic peroxisome proliferation, lipofuscin accumulation and cell turnover for the hepatocarcinogens Wy-14,643 and clofibric acidCarcinogenesis: Integrative Cancer Research, 1992
- Comparative studies on nafenopin-induced hepatic peroxisome proliferation in the rat, Syrian hamster, guinea pig, and marmosetToxicology and Applied Pharmacology, 1989