Prevention by Dietary Means of the Direct Calcification Induced by KMnO4

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Abstract
Experiments on rats indicate that the topical direct calcinosis, normally induced in the subcutaneous connective tissue at the site of KMnO4-injection, is prevented if the animals are maintained on a diet virtually deficient in both Ca and P. Replacement with calcium acetate does not alter this refractory state, while the administration of Na2HPO4, either alone or in combination with calcium acetate, restores normal reactivity. It is concluded that, for the production of topical calcinosis with KMnO4, the dietary intake of phosphate is of decisive importance, while the Ca content of the diet plays little or no role in this phenomenon.

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