Ca2+‐dependent inhibition by trifluoperazine of the Na+‐Ca2+ carrier in mitoplasts derived from heart mitochondria

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Abstract
The interaction of trifluoperazine and extramitochondrial Ca2+ with the heart mitochondrial Na+‐Ca2+ carrier has been investigated. External Ca2+ inhibits the carrier equally in mitochondria and mitoplasts in which the outer membrane is lysed. Sensitivity to Ca2+ is not removed by washing mitoplasts under varied conditions. Trifluoperazine is a potent inhibitor of the carrier in mitoplasts but not in mitochondria. Trifluoperazine inhibition in mitoplasts depends markedly on the presence of extramitochondrial Ca2+ (2 μM)