Voltage‐dependent calcium entry in confluent bovine capillary endothelial cells
- 1 March 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 299 (3) , 239-242
- https://doi.org/10.1016/0014-5793(92)80123-x
Abstract
Confluent bovine capillary endothelial cells display, when examined for voltage-dependent calcium entries using cell-attached channel recordings, two types of Ca2+ channels (4 and 23.5 pS in 110 mM Ba2+) both sensitive to the dihydropyridine Ca agonist BAY K 8644. In contrast to isolated cells, confluent cells display no T-type, low threshold activity, and Ca currents were typically only elicited at very depolarized potentials. In these cells, voltage-dependent calcium entries will only be made operative by substances able to shift their activation towards the resting potential.Keywords
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