Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579

This publication has 74 references indexed in Scilit:

• Phosphodiesterase-4 as a potential drug target
  Emerging Therapeutic Targets, 2005
• Keynote review: Phosphodiesterase-4 as a therapeutic target
  Drug Discovery Today, 2005
• In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region
  Cellular Signalling, 2005
• Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract
  FEBS Letters, 2005
• Pulmonary and Systemic Oxidant/Antioxidant Imbalance in Chronic Obstructive Pulmonary Disease
  Proceedings of the American Thoracic Society, 2005
• PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex
  Biochemical Journal, 2004
• Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene
  Biochemical Journal, 2004
• Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte‐macrophage differentiation of human U937 cells
  British Journal of Pharmacology, 2004
• Short Term Feedback Regulation of cAMP in FRTL-5 Thyroid Cells
  Journal of Biological Chemistry, 2000
• The cyclic AMP system andDrosophila learning
  Molecular and Cellular Biochemistry, 1995