The Effect of ACTH Administration on Serum Estrogens, LH, and FSH in the Aged
- 1 January 1976
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 42 (1) , 88-90
- https://doi.org/10.1210/jcem-42-1-88
Abstract
The effect of administration of longacting ACTH on serum levels of estrogens, LH and FSH was studied in aged subjects. Nine women and 5 men between 66 and 90 years of age were examined. One milligram of long-acting synthetic ACTH was given im every 12 h for 2 days. Significant increases in serum estrone and estradiol levels were induced in parallel with serum cortisol at 24 hours and no further change was observed at 48 hours. The estrone/estradiol ratio increased from a control value of 3.0 to 4.0 at 24 hours and to 4.7 at 48 hours. Changes in mean serum LH and FSH levels were not significant except for a decrease in FSH at 48 hours (P < 0.02) compared to control values.Keywords
This publication has 2 references indexed in Scilit:
- Plasma Precursors of Estrogen. I. Extent of Conversion of Plasma Δ4-Androstenedione to Estrone in Normal Males and Nonpregnant Normal, Castrate and Adrenalectomized FemalesJournal of Clinical Endocrinology & Metabolism, 1967
- Simple Method for the Determination of Plasma CorticoidsJournal of Clinical Endocrinology & Metabolism, 1963