Erroneous Gender Identification by the Amelogenin Sex Test
- 1 March 2004
- journal article
- other
- Published by ASTM International in Journal of Forensic Sciences
- Vol. 49 (2) , 1-2
- https://doi.org/10.1520/jfs2003223
Abstract
Human gender identification, based on the amelogenin gene, has important applications in forensic casework, prenatal diagnosis, DNA databasing, and blood sample storage. However, we report on the first known case, in the Israeli population, of an amelogenin sex test failure on a phenotypically normal male. He was typed as a female by both the AmpFℓSTR® SGM plus™ and GenePrint™ kits. Subsequent, karyotyping of the soldier's blood sample showed no abnormalities. These results suggest that the determination of sex, based on the amelogenin test, should be interpreted cautiously.Keywords
This publication has 6 references indexed in Scilit:
- Rare failures in the amelogenin sex testInternational journal of legal medicine, 2002
- Is the amelogenin gene reliable for gender identification in forensic casework and prenatal diagnosis?International journal of legal medicine, 2002
- Reliability of DNA-based sex testsNature Genetics, 1998
- PCR Amplification of Animal DNA with Human X-Y Amelogenin Primers Used in Gender DeterminationJournal of Forensic Sciences, 1995
- The X-Y homologous gene amelogenin maps to the short arms of both the X and Y chromosomes and is highly conserved in primatesGenomics, 1992
- A human X-Y homologous region encodes “amelogenin”Genomics, 1991