Immunologic Tolerance in Thymectomized, Irradiated Rats Grafted with Thymus from Tolerant Donors
- 4 June 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 148 (3675) , 1333-1335
- https://doi.org/10.1126/science.148.3675.1333
Abstract
Lewis rats, thymectomized at 5 weeks of age and irradiated at 8 weeks, received grafts of adult thymus and marrow, one or both grafts being derived from donors tolerant to bovine γ-globulin. Challenge 3 or 6 weeks after grafting showed that delayed sensitization could not be induced in animals which received a tolerant thymus or tolerant thymus and marrow, though sensitization to a heterologous antigen (chicken ovalbumin) occurred normally. Arthus reactivity was regained slowly in animals receiving normal thymus and marrow and, to an equal extent, in those receiving grafts from tolerant donors.Keywords
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