Decreased β-Adrenergic Sensitivity in Insulin-Dependent Diabetic Subjects

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Abstract
To study β-adrenergic sensitivity in diabetes mellitus, we performed isoproterenol sensitivity tests in 34 insulin-dependent diabetic patients and 10 age-matched normal subjects.β-adrenergic sensitivity [defined as the dose of isoproterenol required to increase the resting heart rate by 25 beat/min, (I2s)] was significantly higher in the diabetic group (4.07 ±1.4 µg, mean ± SD) than in the normal group (2.02 ± 1.49 µg). A comparison of I25 of normal subjects and diabetic patients as a function of age showed that the latter were significantly less sensitive to β-adrenergic stimulation at all ages (P < 0.01). In diabetic patients, β-adrenergic sensitivity also increased with the duration of diabetes (r = 0.64, P< 0.0005), but the correlation was stronger when the age of the patients and the duration of the diabetes were both taken into consideration (r = 0.72, P <0.0005). We conclude that β-adrenergic sensitivity is diminished in patients with type I diabetes mellitus of all ages

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