NEURONAL DISEASE ASSOCIATED WITH INTRACYTOPLASMIC INCLUSION BODIES

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Abstract
Striking alterations in neurons are often seen in the brains of patients who had manifested various clinical symptoms. There appears to be present a primary neuronal condition, which begins with hyperchromatic alterations of the Nissl material, progresses to a ragged, tattered appearance of the nerve cells and leads gradually to alteration of the chromatic particles, formation of vacuoles in the nerve cell and deformation of the nerve cell and its dendritic processes. When this stage is reached, the disease can readily be recognized under the microscope. Then follows a stage of impoverishment of the nerve cell and degeneration of its cytoplasmic constitution, leading to formation of a shadow cell; the process may pass on to final dissolution, represented by fragmentation of the structural protein of the cell body and the remnant of a naked nucleus. When the process is slow and inconclusive, local areas in the cell may show encrustations

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