Receptor heterodimerization leads to a switch in signaling: β‐arrestin2‐mediated ERK activation by μ‐δ opioid receptor heterodimers
Open Access
- 23 March 2007
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 21 (10) , 2455-2465
- https://doi.org/10.1096/fj.06-7793com
Abstract
Opiates are analgesics of choice in the treatment of chronic pain, but their long‐term use leads to the development of physiological tolerance. Thus, understanding the mechanisms modulating the respo...Keywords
Funding Information
- National Institutes of Health (DA08863, DA019521)
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