The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1‐1 in two different modes
Open Access
- 8 December 1997
- journal article
- Published by Wiley in FEBS Letters
- Vol. 419 (1) , 32-36
- https://doi.org/10.1016/s0014-5793(97)01424-5
Abstract
The diuretic drug ethacrynic acid, an inhibitor of pi class glutathione S‐transferase, has been tested in clinical trials as an adjuvant in chemotherapy. We recently solved the crystal structure of t...Keywords
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