COMPARATIVE SURVIVAL OF PANCREATIC ISLETS, HEART, KIDNEY, AND SKIN ALLOGRAFTS IN RATS, WITH AND WITHOUT ENHANCEMENT
- 30 June 1977
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 24 (1) , 70-73
- https://doi.org/10.1097/00007890-197707000-00010
Abstract
Enhancement of (AS X Aug)F1 pancreatic islet allograft survival in diabetic AS rats was achieved by treating the recipient with a course of antidonor antiserum. Their survival in untreated and treated recipients was compared with the survival of transplanted heart, kidney and skin allografts similarly treated. The islet allografts were rejected by a mean of 8.3 days. In the enhanced group all of the kidney allografts, 7 of 11 heart allografts and 4 of 10 islet allografts had a prolonged survival, whereas none of the skin allografts had a prolonged survival. Islet allografts are more susceptible to rejection than other tissues, but their survival can be prolonged using specific immunosuppression. The reasons for the increased susceptibility to rejection are discussed.This publication has 1 reference indexed in Scilit:
- PASSIVE ENHANCEMENT OF ISOLATED PANCREATIC ISLET ALLOGRAFTSTransplantation, 1976