Oncogenic Transformation and hyperthermia

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Abstract
The potential of hyperthermia for producing oncogenic transformation in vitro was assessed using C3H/10T 1/2 mouse embryo cells. Temperatures in the range of 40-45.degree. C caused no transformations, whether or not the heat treatment was associated with significant cell killing. Modest hyperthermia appreciably reduced the transformation frequencies associated with X-ray doses. The findings suggest an additional benefit in combining ionizing radiations with hyperthermia.