STRONTIUM AND ITS RELATION TO CALCIUM METABOLISM*

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Abstract
When the rates of loss of Sr into urine (vu), feces (vf) and bone (vo+) are expressed as a fraction of the total circulating mass of Sr in the body (M), the resulting fractional rate constants (ku, kf, ko+) are independent of the scheme chosen, i. e. whether it is a system with or without constant pool. This permits a detailed comparison of Sr with Ca metabolism, even though the existence of a central pool has been demonstrated only for Ca. In 15 studies on 8 patients the ratio ku (Sr): kf (Ca) varied from 1.2 to 5.7, mean 2.95; the ratio of ko+ (Sr): ko+ (Ca) varied from 0.4 to 1.5, mean 1.11; and the ratio k0+ (Sr): k0. (Ca) varied from 0.6 to 1.6, mean 0.99. These wide variations preclude the use of Sr as a tracer in studies of human Ca metabolism, though Sr may conceivably serve as a qualitative indicator of changes in vo+ in population, but not in individual patient, studies.

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