CHEDIAK-HIGASHI-SYNDROME OF CATS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 36  (5) , 554-562
Abstract
Initial clinical, genetic, cytochemical and ultrastructural studies have characterized the Chediak-Higashi syndrome in cats. Three cats with Chediak-Higashi syndrome were found in a single line of 27 Persian cats, and 3 additional affected cats were produced from 2 prospective breedings of the original line. The disorder was characterized an autosomal recessive condition. All cats in the line with the combination of yellow eye color and blue smoke hair color exhibited the disorder. Four of the 5 cats examined had bilateral nuclear cataracts as early in life as 3 mo. of age. No increased susceptibility to infectious disease was observed. A bleeding tendency was noted. Abnormally large eosinophilic, sudanophilic, peroxidase-containing granules were observed in the neutrophils of the granulocytic series of blood and bone marrow by EM and light microscopy. Granules of eosinophils and basophils were also enlarged. Light microscopic studies of hair and skin revealed enlarged melanin granules. These manifestations were similar to those in man, mink, cattle, mice, and the killer whale with Chediak-Higashi syndrome. Cats are the 6th species in which this genetic disease was reported.