Radiosensitizers targeted to DNA using platinum. Synthesis, characterisation, and DNA binding of cis-[PtCl2(NH3)(nitroimidazole)]
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 13,p. 1043-1044
- https://doi.org/10.1039/c39870001043
Abstract
The preparation and characterisation of cis-[PtCl2(NH3)(misonidazole)] and cis-[PtCl2(NH3)(metronidazole)] is reported; these complexes bind to DNA and radiosensitize more efficiently than their analogues containing two nitroimidazole groups, and the results confirm the possibility of targeting radiosensitizing ligands to DNA by complexation with platinum.Keywords
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