Zinc Uptake in Normal and Leukemic Lymphocytes: Effect of Poly-l-ornithine2

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Abstract
Phytohemagglutinin and poly-l-ornithine were tested for their ability to stimulate uptake of transferrin-bound zinc by lymphocytes from both normal donors and donors with chronic lymphocytic leukemia. The ratio of zinc uptake in poly-l-ornithine cultures to zinc uptake in phytohemagglutinin cultures was 0.9±0.3 for leukemic lymphocytes and 1.9±0.2 for normal lymphocytes. Results indicated that this technique may be useful in the diagnosis of chronic lymphocytic leukemia as well as in the assessment of the efficacy of chemotherapeutic regimens.