EFFECTS OF SHIPPING ON THE IMMUNE FUNCTION IN MICE

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 43  (9) , 1654-1657
Abstract
The effect of shipping stress on immunologic functions was examined in mice. The mice were shipped either by truck or by plane, 2 of the most common modes for transport of animals. While mice were in transit, temperature fluctuations and light intensity were monitored. The foot pad test, hemagglutination assay and plaque-forming cell assay were used to measure immunologic function. Corticosterone concentrations were quantitated with a competitive protein-binding technique. Regardless of the method of shipment, corticosterone values in the mice were markedly increased at arrival and remained at the high value for a 48 h period. Immune function assays were significantly lessened in the mice at arrival, but returned to base line within 48 h, indicating that a minimum 48 h stabilization period is required for all new arrivals.

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