Isocyanates from primary amines and carbon dioxide: ‘dehydration’ of carbamate anions

Abstract
Carbamate anions, derived from primary amines CO2 and an added base (e.g. NEt3), undergo rapid reaction with electrophilic ‘dehydrating agents’(e.g. POCl3, P4O10) to give the corresponding isocyanates in excellent yields.

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