Effects of γ Irradiation on Cartilage Matrix Calcification

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Abstract
The effect of .gamma. irradiation on cartilage matrix calcification was studied in vitro. Metatarsal bones of 14-17 day old embryonic mice were dissected and cultured under various conditions. Prior to culture 1/2 of the metatarsal bones received absorbed doses of 1.0-30.0 Gy [grays] .gamma. radiation. Their paired counterparts served as controls. Irradiation inhibited longitudinal growth and calcification of the cartilage matrix during culture. A number of histological changes were noted. The inhibition of matrix calcification appeared due to an inhibition of the intracellular Ca accumulation. The formation of extracellular calcification foci and the growth of the calcified area already present at the moment of explantation were not inhibited during culture.

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