Effects of Cilazaprilat and Enalaprilat on Experimental Dermatitis in Guinea Pigs

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Abstract
Two non‐sulfur containing ACE‐inhibitors were tested concerning their local effect on experimental dermatitis in ovalbumin‐sensitized guinea pigs. Enalaprilat but not cilazaprilat potentiated the ovalbumin‐evoked inflammatory response. Futhermore, enalaprilat clearly enhanced the erythema evoked by substance P, whereas cilazaprilat did not. Concerning, the bradykinin‐evoked erythema, enalaprilat significantly potentiated the response, whereas cilazaprilat only caused a slight increase. Our results suggest that different affinities for peptidases involved in degradation of inflammatory peptides can explain differences between the pro‐inflammatory properties of enalaprilat and cilazaprilat.