Optically Active Amines by Enzyme-Catalyzed Kinetic Resolution
- 11 June 2008
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 2008 (14) , 2283-2287
- https://doi.org/10.1055/s-2008-1078451
Abstract
Chiral amines are resolved by an enzyme-catalyzed kinetic resolution. Key steps are the selective acylation of one enantiomer with isopropyl methoxyacetate, separation of the resulting amide from the unreacted antipode, and finally amide hydrolysis. The process proceeds with excellent selectivity and is highly flexible with regard to substrates.Keywords
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