ESTROGEN-PRODUCING SERTOLI CELL TUMORS (ANDROBLASTOMA TUBULARE LIPOIDES) OF THE HUMAN TESTIS AND OVARY. HOMOLOGOUS OVARIAN AND TESTICULAR TUMORS. III.*†

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Abstract
In continuation of previous studies on identical tumors of the ovary and the testis, a morph. congruence is demonstrated between the feminizing androblastoma (tubulare lipoides) testis and feminizing ovarian tumors which have previously been described as "folliculome lipidique" or granulosa cell tumors of tubular or adenomatous type. These ovarian tumors can thus be classified as androblastomas, i.e., tumors originating from a testicular blastema in which a differentiation tending in the direction of Sertoli and (or) Leydig cells may take place. The estrogenic effect of androblastoma tubulare lipoides of the human ovary as well as of the testis is explained by dominance of tubular portions (Sertoli cells) in accordance with Huggins and Moulder''s demonstration of estrogen-producing, lipidic (often tubular) Sertoli cell tumors in dog. Similarly, the hormonal effect of virilizing androblastomas, i.e., arrheno-blastomas and Leydig cell tumors (so-called "adrenal cell tumors" and "luteomas"), is supposed to depend on a dominance of androgen-producing Leydig cells. Through the histogenetical classification of the androblastomas the following, hitherto inexplicable, points are elucidated That the "most highly differentiated" (i.e., chiefly tubular) arrhenoblastomas have the least pronounced (frequently lacking) hormonal (i.e., virilizing) effect.

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