INHIBITION OF THE HEART UNDER ANAEROBIC CONDITIONS

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Abstract
Turtle''s auricles with intact vagi were isolated from the animal and subjected to anaerobic conditions in N, in cyanide solns. and under mineral oil. Neither lack of O nor the accompanying accumulation of lactic acid caused inhibition of the cardiac muscle; the inhibitory nerves continued to function under anaerobic conditions as long as contractions were possible. Monoiodoacetic acid prevents the development of lactic acid but does not interfere with inhibition; hence lactic acid plays no role in the inhibitory mechanism.

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