Chromosome 16 and Bone-Marrow Eosinophilia

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Abstract
To the Editor: The discovery by Arthur and Bloomfield1 of an association between a partial deletion of chromosome 16 and bone-marrow eosinophilia in acute nonlymphocytic leukemia appears to be another example of the growing number of specific human cancers associated with specific chromosomal abnormalities. Subsequently, Le Beau et al.2 reported findings suggesting that a pericentric inversion, inv(16)(pl3q22), rather than a deletion, del (16)(q22), may be even more closely associated with the same clinical abnormality.The described deletion suggests loss of a small segment of genetic material (16q22→qter), whereas the inversion suggests an intrachromosomal rearrangement in which nothing is lost or . . .